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James Vaughan may refer to:James Vaughan (priest), Dean of Achonry, Ireland, from 1662 to 1683 James Vaughan (magistrate) (1814-1906), British magistrate James David Vaughan (1864–1941), American musician James Churchill Vaughan (1893–1937), Nigerian physician James H. Vaughan (1934–1996), Canadian politician James J. Vaughan (1870–1935), American composer James Vaughan, English right-back James Vaughan, English former footballer James Vaughan, English footballer for Chattanooga Red Wolves James Vaughan, chief constable of Dorset Police James Vaughan, creator of the video game Plague Inc.