At the age of 38, Mark O'Brien, a man who uses an iron lung, decides he no longer wishes to be a virgin. With the help of his therapist and his priest, he contacts Cheryl Cohen Greene, a professional sex surrogate and a typical soccer mom with a house, a mortgage and a husband. Inspired by a true story, The Sessions, follows the fascinating relationship which evolves between Cheryl and Mark as she takes him on his journey to manhood.