Transisthmian Route of Panamá
- States
- Panama
- Category
- Cultural
- Year
- 2025
- Region
- Latin America & Caribbean
- Coordinates
- 9.3231722222, -79.999775
- Last Visited
- 2026
- UNESCO ID
- 1582
- WH Site
- 1582
The Colonial Transisthmian Route of Panamá, a UNESCO World Heritage site, is a historic network of paths and fortifications that connected the Pacific and Caribbean coasts during the Spanish colonial period (1501–1821). Comprising Panamá Viejo, Casco Antiguo, Portobelo, San Lorenzo, and the Camino Real and Cruces roads, it facilitated the transport of South American silver and goods, shaping global trade. This route, a precursor to the Panama Canal, showcases military architecture and cultural exchanges.