Museo Nacional Centro de Arte Reina Sofía, located in the heart of Madrid, is a treasure trove of 20th-century Spanish art. It's renowned for housing an impressive collection that includes works by Salvador Dalí and Joan Miró. However, its most famous piece is Pablo Picasso's 'Guernica', a powerful political statement against the atrocities of war. The museum itself is a blend of classic and modern architecture, offering a unique cultural experience that extends beyond its vast galleries.